Marja T Nevalainen Selected Research

STAT5 Transcription Factor

10/2019	Positive STAT5 Protein and Locus Amplification Status Predicts Recurrence after Radical Prostatectomy to Assist Clinical Precision Management of Prostate Cancer.
6/2013	STAT5A/B gene locus undergoes amplification during human prostate cancer progression.
10/2011	Signal transducer and activator of transcription 5a/b: biomarker and therapeutic target in prostate and breast cancer.
2/2011	Targeting transcription factor Stat5a/b as a therapeutic strategy for prostate cancer.
12/2010	N-terminal truncation of Stat5a/b circumvents PIAS3-mediated transcriptional inhibition of Stat5 in prostate cancer cells.
2/2010	Transcription factor Stat5a/b as a therapeutic target protein for prostate cancer.
1/2010	Activating mutation (V617F) in the tyrosine kinase JAK2 is absent in locally-confined or castration-resistant prostate cancer.
6/2008	Signal transducer and activator of transcription 5A/B in prostate and breast cancers.
3/2008	Transcription factor signal transducer and activator of transcription 5 promotes growth of human prostate cancer cells in vivo.
1/2008	Transcription factor Stat5 synergizes with androgen receptor in prostate cancer cells.

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Marja T Nevalainen Research Topics

Disease

31	Prostatic Neoplasms (Prostate Cancer) 10/2021 - 07/2003
24	Neoplasms (Cancer) 01/2022 - 06/2004
8	Breast Neoplasms (Breast Cancer) 01/2022 - 05/2002
6	Neoplasm Metastasis (Metastasis) 09/2021 - 06/2004
2	Myeloproliferative Disorders (Myeloproliferative Disorder) 11/2020 - 01/2010
2	Leukemia 10/2018 - 08/2015
2	Disease Progression 10/2013 - 01/2010
1	Adenocarcinoma 01/2021
1	Philadelphia Chromosome 10/2018
1	Precursor Cell Lymphoblastic Leukemia-Lymphoma (Acute Lymphoblastic Leukemia) 10/2018
1	Carcinogenesis 05/2002
1	Hyperplasia 01/2002

Drug/Important Bio-Agent (IBA)

14	STAT5 Transcription FactorIBA 10/2019 - 05/2002
11	Proteins (Proteins, Gene)FDA Link 01/2020 - 07/2004
9	Androgen Receptors (Androgen Receptor)IBA 10/2021 - 01/2008
7	AndrogensIBA 10/2021 - 01/2002
7	ProlactinIBA 09/2021 - 07/2004
5	Phosphotransferases (Kinase)IBA 10/2018 - 07/2004
5	Biological ProductsIBA 10/2011 - 01/2005
4	Tyrosine (L-Tyrosine)FDA Link 08/2015 - 07/2003
4	DNA (Deoxyribonucleic Acid)IBA 03/2015 - 03/2008
4	Hormones (Hormone)IBA 10/2008 - 07/2007
3	Biomarkers (Surrogate Marker)IBA 01/2017 - 10/2011
3	Cadherins (E-Cadherin)IBA 09/2015 - 01/2005
3	Transcription Factors (Transcription Factor)IBA 04/2010 - 05/2002
3	Protein-Tyrosine Kinases (Tyrosine Kinase)IBA 01/2010 - 07/2004
2	Estrogen ReceptorsIBA 09/2021 - 06/2004
2	CytokinesIBA 10/2020 - 05/2014
2	enzalutamideIBA 01/2020 - 03/2015
2	Androgen Antagonists (Antiandrogens)IBA 01/2020 - 03/2015
2	Messenger RNA (mRNA)IBA 01/2020 - 01/2018
2	AZD 1480IBA 05/2014 - 10/2013
2	STAT3 Transcription Factor (Signal Transducer and Activator of Transcription 3)IBA 04/2010 - 06/2008
2	LigandsIBA 01/2010 - 07/2004
2	Intercellular Signaling Peptides and Proteins (Growth Factors)IBA 03/2008 - 07/2007
2	ParaffinIBA 08/2005 - 06/2004
1	Pharmaceutical PreparationsIBA 09/2021
1	Phenobarbital (Luminal)FDA Link 09/2021
1	Estrogens (Estrogen)FDA Link 09/2021
1	Janus Kinase InhibitorsIBA 10/2020
1	Tyrosine Kinase InhibitorsIBA 10/2018
1	SynaptophysinIBA 11/2016
1	IntegrinsIBA 11/2016
1	VimentinIBA 09/2015
1	Fibronectins (Fibronectin)IBA 09/2015
1	Prostate-Specific Antigen (Semenogelase)IBA 03/2015
1	Flutamide (Eulexin)FDA LinkGeneric 03/2015
1	bicalutamide (Casodex)FDA LinkGeneric 03/2015
1	Interleukin-6 (Interleukin 6)IBA 05/2014
1	Docetaxel (Taxotere)FDA Link 10/2013
1	Estrogen Receptor Modulators (Antiestrogen)IBA 06/2011
1	Prolactin Receptors (Prolactin Receptor)IBA 02/2011
1	Dihydrotestosterone (Androstanolone)IBA 10/2008
1	Protein Kinases (Protein Kinase)IBA 06/2008
1	Therapeutic UsesIBA 06/2008
1	Janus KinasesIBA 06/2008
1	Cyclin D1IBA 03/2008
1	Antisense OligonucleotidesIBA 03/2008
1	MitogensIBA 07/2007
1	beta CateninIBA 01/2005
1	Matrix Metalloproteinases (MMPs)IBA 01/2005
1	Tumor Biomarkers (Tumor Markers)IBA 01/2005
1	matrigelIBA 01/2005
1	Janus Kinase 2IBA 07/2004
1	Progesterone Receptors (Progesterone Receptor)IBA 06/2004

Therapy/Procedure

16	Therapeutics 10/2021 - 06/2008
3	Radiotherapy 01/2021 - 01/2018
3	Castration 12/2010 - 01/2010
2	Precision Medicine 09/2021 - 10/2019
2	Prostatectomy (Retropubic Prostatectomy) 10/2019 - 03/2013
1	Adjuvant Chemotherapy 01/2022
1	Drug Therapy (Chemotherapy) 10/2018